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008			110127s2010 mdua b f001 0 eng
010			_a 2010443804
020			_a9780160840784 (pbk.) : _c66.00
020			_a0160840783 (pbk.) : _c66.00
050	0	0	_aRA1242.T6 _bH69 2010
090			_aRA 1242 .T6 H69 2010
245	0	0	_aHow tobacco smoke causes disease : _bthe biology and behavioral basis for smoking-attributable disease : a report of the Surgeon General.
246	3	0	_aBiology and behavioral basis for smoking-attributable disease
246	3	0	_aReport of the Surgeon General
260			_aRockville, MD : _bU.S. Dept. of Health and Human Services, Public Health Service, Office of the Surgeon General ; _aWashington, DC : _bFor sale by the Supt. of Docs., U.S. G.P.O., _c2010.
300			_axv, 704 p : _bill. (some col.) ; _c28 cm.
505	0		_a Ch. 1: Introduction, Evaluation of Evidence on Mechanisms of Disease Production, and Summary -- Introduction -- Evaluation of evidence on mechanisms of disease production -- Mechanisms of action: necessary, sufficient, or neither -- Description of evidence on mechanisms of disease production -- Scientific basis of the report -- Development of the report -- Major conclusions -- Chapter conclusions -- References -- Ch. 2: The Changing Cigarette -- Introduction -- Cigarette design changes over the years -- New cigarette products -- Low-nicotine cigarettes -- Cigarette-like products -- Evaluation of new cigarette products -- New oversight of tobacco products -- Summary -- Conclusions -- References -- Ch. 3: Chemistry and Toxicology of Cigarette Smoke and Biomarkers of Exposure and Harm -- Introduction -- Chemistry -- Biomarkers -- Summary -- Conclusions -- References -- Ch. 4: Nicotine Addiction: Past And Present -- Introduction -- Definition of nicotine addiction -- Tobacco constituents and pharmacokinetics -- Components of nicotine addiction -- Pathophysiology of nicotine addiction -- Genetics -- Prevalence and trajectory toward nicotine dependence -- Epidemiology of tobacco use and nicotine dependence in adults -- Trajectory of recovery or relapse -- Evidence summary -- Conclusion -- References -- Ch. 5: Cancer -- Introduction -- Carcinogen exposure, metabolism, and DNA adducts -- DNA repair and conversion of adducts to mutations -- Gene mutations in tobacco-induced cancer -- Loss of mechanisms for growth control -- Other aspects -- Evidence summary -- Conclusions -- References -- Ch. 6: Cardiovascular Diseases -- Introduction -- Tobacco use and cardiovascular disease -- Secondhand tobacco smoke and cardiovascular disease -- Pathophysiology -- Hemodynamic effects -- Smoking and the endothelium -- Thrombogenic effects -- Inflammation -- Smoking and diabetes -- Lipid abnormalities -- Cardiovascular biomarkers -- Smoking cessation and cardiovascular disease -- Methods to reduce exposure -- Evidence summary -- Conclusions -- References -- Ch. 7: Pulmonary Diseases -- Introduction -- Smoking and respiratory defense mechanisms -- Oxidative stress -- Oxidative stress in chronic obstructive pulmonary disease -- Genetics of pulmonary disease and susceptibility to tobacco smoke -- Pathogenesis of emphysema -- Summary -- Evidence summary -- Conclusions -- Implications -- References -- Ch. 8: Reproductive and Developmental Effects -- Introduction -- Review of epidemiologic literature on smoking -- Pathophysiological and cellular and molecular mechanisms of smoking -- Implications -- Evidence summary -- Conclusions -- References -- Ch. 9: A Vision for the Future -- The global tobacco epidemic -- Reducing the risks from smoking -- Ending the tobacco epidemic -- Concluding remarks -- Appendix 9-1: Recommendations for future research -- Appendix 9-2: Ending the tobacco problem: a blueprint for the nation -- Appendix 9-3: Promoting healthy lifestyles: policy, program, and personal recommendations for reducing cancer risk -- References -- List of abbreviations -- List of tables and figures -- Definitions and alternative nomenclature of genetic symbols used in this report -- Index.
504			_aIncludes bibliographical references and index.
650		0	_aTobacco use _xHealth aspects. _9128332
650		0	_aSmoking _xHealth aspects. _957168
650		0	_aTobacco smoke pollution _xHealth aspects. _9128334
710	1		_aUnited States. _bPublic Health Service. _bOffice of the Surgeon General. _9128336
852	1		_9P66.00usd
907			_a36184 _b07-17-12 _c07-17-12
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